UPTU Exam Question Papers
B Tech 4th Semester Genetics and Molecular Biology 2006-07
Note : (1) Attempt all questions.
(2) All questions carry equal marks.
1. Attempt any four parts of the following :
(a) Explain the physical basis of segregation.
(b) Differentiate between complementary and inhibitory gene interactions.
(c) Why translocation heterozygotes show partial sterility?
(d) Explain the meaning of repulsion and coupling phase linkages.
(e) Explain the mechanism of mutation induced by intercalating agents.
(f) Explain the consequence and mechanism of mismatch repair.
2. Attempt any four parts of the following:-
(a) How did the observations of E.Chargaff help Watson & Crick in proposing double helix?
(b) How can you differentiate between prokaryotic and eucaryotic genomes on the basis of Cot curves?
(c) How is replication of genome of E.coli initiated at Oric?
(d) How are the telomeric regions replicated in eukaryotes?
(e) What is retrotransposition? Briefly explain.
(f) What was the contribution of Morgan to the chromosomal basis of heredity?
3. Attempt any two parts of the following :
(a) Describe the key features of shotgun approach in genome sequencing.
(b) How is proteomics useful in understanding functions of different proteins?
(c) If you are given the nucleotide sequence of a piece of DNA, how would you proceed to demonstrate its evolutionary relatedness to other sequences in the database?
4. Attempt any two parts of the following:-
(a) Explain the main features of transcription of genes transcribed by RNA polymerase II.
(b) Explain the differences between prokaryotic and eukaryotic translation process.
(c) Explain the mechanism of poly A tailing at 3’ end of the transcripts produced by RNA polymerase II.
5. Attempt any two parts of the following:
(a) Explain the role played by ribosomal RNA in the process of translation.
(b) How was it proved that genetic code is degenerate?
(c) How is transcription initiated in E. Coli?