Organic Chemistry Syllabus
B.Tech. (BT)Second Semester
EURCH209: Organic Chemistry
Code: EURCH 209 Category: BS
Credits:4 Hours : 4 per week
Department : Engg. Chemistry
Structure and Properties: Elemental analysis – determination of percentage
composition of carbon, Hydrogen, Nitrogen, chlorine and oxygen. Empirical and
molecular formula – simple numerical problems. Isomerism – Basics of optical and
geometrical Isomerism, R & S and E & Z configuration. Stereoisomerism of
Cyclic Aliphatic Hydrocarbons,1,3 diaxial interaction (Boat, Chair and Twisted Boat
conformations of cyclohexane and 1- methyl cyclohexane). Polymerization –
Ziegler – Natta polymerization, preparation of Polyethylene, PVC and Bakelite;
Rubber – isoprene rule, vulcanization. Soaps and detergents – preparation and
cleansing action. Elementary Problems based on reactions of organic compounds.
Aliphatic compounds: Alkanes – preparation by Wurtz Reaction, Hydrolysis of
Grignard reagent. Free Radical Substitution (Mechanism of halogenation), Energy of
activation and transition state; Alkenes – Industrial preparation of Ethylene, 1, 2
elimination reactions (E1 and E2 mechanisms), Electrophilic and Free Radical
Addition reactions (Markovnikov’s and anti Markovnikov’s rule). Alkynes –
industrial preparation of acetylene, acidity of alkynes; Dienes – 1, 2 vs 1, 4 addition
(electrophilic addition), Diels – Alder Reaction. Cyclic aliphatic compounds –
Bayer’s strain theory. Alkyl halides – SN1, SN2 reactions with mechanisms
Aromatic compounds: Benzene – Aromatic Character, Mechanism of Electrophilic
Aromatic Substitution – Nitration, Sulphonation, Halogenation, Friedel – Crafts
Alkylation and Acylation – Orientation of disubstituted Benzenes – activating and
deactivating groups. Arenes – Friedel – Crafts Alkylation and its Limitations,
Clemmenson and Wolf – Kishner’s reductions. Aryl halides – Sandmeyer and
Gattermann reactions, Nucleophilic aromatic substitution. Phenols – Industrial
preparation of phenol, Acidity of phenols, Fries rearrangement, Kolbe’s reaction,
Reimer- Tiemann reaction.
Carboxylic acids and Derivatives: Industrial preparation of acetic, benzoic and
phthalic acids. Effect of substitutents on acidity, HVZ reaction, Hoffman Bromamide
reaction and Claisen condensation; Preparation and applications of Malonic Ester and
Acetoacetic Ester. Keto-enol tautomerism.
Amines : Industrial preparation of Aniline and aliphatic amine – Reductive amination,
Hoffmann elimination, Benzidine rearrangement; Effect of substituents on basicity,
Distinguishing tests for amines. Preparation and synthetic applications of Diazonium
salts. Sulpha Drugs – preparation of sulphanilamide, antibacterial activity.
Alcohols: Alcohols – Industrial preparation of Ethyl Alcohol, Grignard synthesis of
alcohols, Differentiation tests of alcohols, Williamson synthesis of Ethers.
Aldehydes and ketones: Preparation by oxidation of alcohols, Differentiation tests,
Nucleophilic addition reactions – Cannizaro reaction, Aldol Condensation, Perkin,
Reformatsky and Wittig reactions. Carbohydrates: Classification, Stereochemistry,
reactions of Glucose and Fructose and their interconversions, Kiliani–Fischer
Synthesis, Ruff degradation and Wohl’s degradation.
Text Book Prescribed:
Text book of organic chemistry by R.T Morrison and R.N Boyd.
1. A Text book of Organic Chemistry by I.L.Finar (Vol.1) Longman group.
2. A Text book of Organic Chemistry by L.G. Wade, Jr. Pearson education.
3. A Text book of Organic Chemistry by Francis A. Carey. Tata Mc Graw – Hill.