GITAM University Bio Reactor Design Syllabus
B.Tech. (BT) VIII Semester
Code : EURBT 801 Category: CE
Credits: 3 Hours : 3 per week
Microbial, plant and animal cell culture – Batch, Continuous and Fed-batch culture.
Kinetic relationships – parameters, variables and constraints, simple problems on the
Mass Transfer in Bioreactors: Importance of interfacial mass transfer in
Biotechnology. Mass Transfer between phases – factors affecting mass transfer
between phases. Mass Transfer in porous solids. Oxygen uptake in fermenters.
Simple problems on topics.
Design of a Fermenter:
Basic functions of a fermenter for microbial or animal cell culture. Aseptic operation,
sterilization and containment, temperature control. Reactor body construction –
construction material. Reactor Dynamics. Design calculation for stirred tank Bioreactor.
Simple problem on it.
Rheology, Aeration and Agitation in Animal Cell Bioreactors
Design, Operation and types of agitators and spargers, power and time requirements
for agitation. Effects of agitation on mass transfer, Oxygen delivery system, foam
control system, factors affecting antifoam requirements, Antifoam addition system.
Types of Reactors and Accessories:
Description, working, advantages and limitations of stirred tank, Airlift, Bubbledriven,
packed bed, fluidized bed, trickle bed and flocculated cell Bioreactors.
Description and functions of the following accessories for bioreactors:
Pumps, filters, valves, steam traps.
1. Biochemical engineering fundamentals, Bailey and Ollis. 2nd Ed. 1986.
2. Principles of Fermentation Technology, Stanbury, P.F.A., Whitaker & Hall, 1997.
1. Introduction to Biochemical Engineering, D.G.Rao, 2005. Tata McGrawHill.
2. Basic Bioreactor Design – Van’t Riet, K & J,Tramper, Marcel Dekkar Inc. New