Experimental Pharmacology - III

This book has been written in the hope that our experience will be of value to others facing problems for developing suitable practical courses. We hope that, this collection of experiments will be of real value to teachers and students of pharmacy profession. We also hope that they will adapt, modify and extend them so that practical classes in pharmacology may be really useful and stimulating experience for students. If this book helps to provide the reader with a clear understanding of the basic concepts of experimental pharmacology, then we would consider our object as fulfilled.

1.Dose calculation in pharmacological experiments.

2.Antiallergic activity by mast cell stabilization assay.

3.Study of anti-ulcer activity of a drug using pylorus ligand (SHAY) rat model and NSAIDS induced ulcer model.

4.Study of effect of drugs on gastrointestinal motility.

5.Effect of agonist and antagonists on guinea pig ileum.

6.Estimation of serum biochemical parameters by using semiautoanalyser.

7.Effect of saline purgative on frog intestine.

8.Insulin hypoglycemic effect in rabbit.

9.Test for pyrogens (rabbit method).

10.Determination of acute oral toxicity (LD50) of a drug from a given data.

11.Determination of acute skin irritation / corrosion of a test substance.

12.Determination of acute eye irritation / corrosion of a test substance.

13.Calculation of pharmacokinetic parameters from a given data.

14.Biostatistics methods in Experimental Pharmacology (central tendency)

15.Biostatistics methods in Experimental Pharmacology (student’s t test, ANOVA).

16.Biostatistics methods in Experimental Pharmacology (Chi-square test, Wilcoxon Signed Rank test).