# UPTU Previous Question Papers

# B Tech 6th Semester Bioinformatics-2 2006-07

**Note : Attempt all questions.**

**1. Attempt any two parts of the following :**

(a) Enumerate few key inference problems in molecular biology. Differentiate between Orthologous and Paralogous sequences.

(b) Describe any one method for protein structure prediction.

(c) What do you mean by protein function prediction ? How is it done, explain with a suitable example.

(d) What is drug discovery? Explain various steps of drug discovery.

**2. Attempt any two parts of the following :**

(a) Explain applications of probability and statistics in Bioinformatics

(b) Explain Clustering and Classification statistical operations, commonly applied to microarray data.

(c) What is Bayes’ rule? Explain Bayes’ theorem applicable in biological system.

(d) Describe Regression and Significance testing methods applied in bioinformatics analysis.

**3. Attempt any two parts of the following :**

(a) Enumerate various Machine learning approaches used in computational biology.

(b) What do you understand by Genetic algorithms? Explain with suitable examples.

(c) Discuss the applications of Support Vector Machine in vaccine designing.

(d) What is artificial neural network? Explain the applications of back propagation method with suitable examples.

**4. Attempt any three parts of the following :**

(a) What is Data mining? Explain data mining applications in genomic sequences.

(b) Describe the general simulation techniques applicable to biological problems.

(c) Explain continuous simulation in biological processes.

(d) What do you mean by bibliographic database? Explain its application with suitable example.

(e) How management information system is applied in bioinformatics?

**5. Attempt any three parts of the following :**

(a) What do you mean by protein-ligand docking, explain with suitable example.

(b) Define Pairwise sequence alignment. Explain difference between global and local alignments with example.

(c) Discuss the recent trends in computational Vaccine designing.

(d) Devise an algorithm to compute the number of distinct optimal alignments between a pair of strings.

(e) Discuss any one computational method for 3-D protein structure modeling.