UPTU Previous Question Papers
B Tech 4th Semester Immunology 2006-07
Note : Attempt all questions.
All questions carry equal marks.
1. Attempt any two parts of the following :
(a) Distinguish between a B cell receptors and T cell receptors.
(b) Explain briefly about the T cell mediated immunity.
(c) Explain briefly about the primary and secondary antibody response.
2. Attempt any two parts of the following :
(a) Explain how antigen is processed and presented on the surface of MHC molecule.
(b) What are antibody isotypes? Describe their characteristic features and functions.
(c) What are the complement proteins? Describe the role of these proteins in regulation and activation of compliment system, and its role in humeral immune response.
3. Attempt any four parts of the following :
(a) Define cytokine, monokine and lymphokine.
(b) Discuss role of interleukines in overall immune regulation.
(c) Elucidate the principle of Radioimmunoassay (RIA).
(d) Explain the mechanism of cell death in negative selection.
(e) Why does precipitation not occur property at the antibody excess zone and the antigen excess zone?
(f) Explain affinity versus avidity of an antibody.
4. Attempt any two parts of the following :
(a) What are hybridomas? How monoclonal antibodies are produced by hybridoma technology ? And add a note on advantage of some over the same produced by genetically engineered microbes.
(b) What are the factors that need to be taken into consideration for immunization strategies with a vaccine?
(c) Explain briefly about the antibody engineering.
5. Attempt any two parts of the following :
(a) Elucidate the role of cytokines in immunity against tumors.
(b) Explain different types of hypersensitive reactions.
(c) Explain the molecular mechanism of interferon action to inhibit multiplication of virus. Justify how the immunity by interferon is considered in nonspecific immunity?