GITAM University Syllabus BE 8th Sem Modelling and simulation in Bioprocesses

GITAM University

Modelling and simulation in Bioprocesses

Syllabus VIII th Semester

 

B.Tech. (BT) VIII Semester

EURBT 842: Departmental Elective: Modelling and simulation in Bioprocesses
Code: EURBT 842 Category: DE
Credits: 3 Hours : 3 per week

UNIT I:
Introduction to Bioprocesses, Modeling and Assessment in Process Development,
Development of Bioprocesses, Types of Bioprocesses and Bioproducts, Bioreaction
Stoichiometry, Thermodynamics and Kinetics, Elements of Bioprocesses, The
Development Process.
UNIT II:
Modeling and Simulation of Bioprocesses: Problem Structuring, Process Analysis
and Process Scheme. Modelling Fundamentals, Formulation of Dynamic Models,
Implementation and Simulation, Uncertainty Analysis.
UNIT III:
Sustainability Assessment. Sustainability, Economic Assessment, Environmental
Assessment, Assessing Social Aspects, Interactions Between the Sustainability
Dimensions.
Bioprocess Case Studies.
UNIT IV:
Citric Acid – Alternative Process Using Starch , Introduction, Fermentation Model,
Process Model, . Inventory Analysis, Environmental Assessment, Economic
Assessment and Conclusions.
L-Lysine – Coupling of Bioreaction and Process Model, Introduction, Basic Strategy,
Bioreaction Model, Process Model, Coupling of Bioreaction and Process Model,
Results and Discussion.
UNIT V:
Penicillin V. Introduction. Modeling Base Case. Inventory Analysis. Environmental
Assessment. Economic Assessment. Monte Carlo Simulations Conclusions.
Recombinant Human Serum Albumin. Introduction Bioreaction Model. Process
Model . Economic Assessment. Ecological Assessment. Conclusions.
?-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures. Introduction.
Process Description. . Model Description. Discussion. Conclusions.
Text Books:
Chemical Engineering Dynamics: An Introduction to Modelling and Computer
Simulation, Third, Completely Revised Edition John Ingham, Irving J. Dunn, Elmar
Heinzle, Jiri E. Prenosil, Jonathan B. Snape (2007)
Development of Sustainable Bioprocesses: Modeling and Assessment,
Elmar Heinzle, Arno P. Biwer, Charles L. Cooney (2007)
Biological Reaction Engineering: Dynamic Modelling Fundamentals with Simulation
Examples, 2nd, Completely Revised Edition
Irving J. Dunn, Elmar Heinzle, John Ingham, Jiri E. Prenosil (2003)

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