Genome Analysis and Bioinformatics : A Practical Approach

Genome Analysis and Bioinformatics : A Practical Approach
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Genome Analysis and Bioinformatics : A Practical Approach

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Publisher: IK International
ISBN: 9789380026367
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About this eBook

Preface
With the decoding of complete genome sequence of many organisms like human, mouse, rice Arabidopsis and many microorganisms new vistas of research have started not only in these species but also in related species by comparative and functional genomics approaches. The published data on genome sequence of these organisms reveals a comprehensive picture of the DNA codes and positions and distribution of all the genes, repetitive sequences and centromeres in the genome. Determination of individual DNA components in the form of ATGC base pairs by using various sequencing techniques and parallel advances in recombinant DNA technology helped in the study of an organism at whole genome level. DNA sequence information is becoming an indispensable tool in modern biology. However, efficient use of this information can only be performed by understanding basics of genomics and bioinformatics. For the application of genome sequence information for the benefits of human being, trained human resource is required. Being associated with the sequencing of rice genome under International Rice Genome Sequencing Project from 2000 to 2005, I was supposed to learn basics of high throughput genome sequencing, sequence assembly, annotation and performing comparative genome analysis at the National Research Centre on Plant Biotechnology NRCPB , IARI, New Delhi and at the Cold Spring Harbor Laboratory, NY, USA as part of my Training on High throughput DNA Sequencing and bioinformatics. It was indeed a great challenge to understand and then apply genomics and bioinformatics techniques in the rice genome analysis. It was also an opportunity to read extensively many good books on molecular biology and bioinformatics. Subsequently, I got an opportunity to design and teach a course on Bioinformatics for the Post Graduate School of the Indian Agricultural Research Institute, New Delhi. During these years, I was using various books and web resources as reading and teaching material. Though I found various interesting and very good books on genomics, molecular biology and bioinformatics, many times it was difficult to understand basics of important topics and then explaining those to the students.
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Preface
I was always looking for a book which includes basic topics on genomics and bioinformatics in a very simple communicable language so that any beginner can start these subjects without any difficulty. To achieve this objective a hybrid book on Genome Analysis and Bioinformatics A Practical Approach was planned. It will definitely act as beginner guide to both biologists who are interested in bioinformatics and to the computer experts who want to make career in bioinformatics. An effort has been made to explain various aspects in a simplest possible manner using well labeled diagrams and figures. For the application of bioinformatics tools, wherever necessary, practical exercises have been included along with different steps so that one can use basic minimum bioinformatics tools without any difficulty. It would be a basic book for researchers and students of B.Tech M.Tech Bioinformatics Biotechnology , all post-graduate students of biology, genetics, genomics biotechnology and even for MCAs etc. At this moment, I would like to thank various individuals who inspired and encouraged me at one or other occasions during my academic life. First of all, I am really very thankful to my teacher, Prof. B.M. Singh, Former Dean, College of Agriculture, Agricultural University, Palampur from whom I have learnt to put my thoughts in a very simple manner. I am grateful to Dr. N.K. Singh, Principal Scientist, NRCPB, with whom I am involved in sequencing rice, tomato and Pigeonpea genomes and shared very good research experiences. I am also very much thankful to the former and present Project Director of NRCPB, for their whole-hearted support and also providing me very congenial teaching and research environment. For the preparation of this book many Research Associates and Research Fellows working in